A negative regulator of the Wnt signalling pathway. Binds to APC (adenomatous polyposis coli protein) and to b -catenin and regulates the stability of the catenin. Interacts directly with glycogen synthase kinase-3 (GSK-3) and promotes GSK-3 phosphorylation of b -catenin, which is then degraded.

Dictionary of molecular biology. 2004.

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